After activation of the intrinsic coagulation system , prekallikrein — with participation of high molecular weight kininogen — is bound to negatively charged surfaces. Factor XIIa then activates it to kallikrein. We differentiate between the hereditary deficiency, which occurs extremely seldom, and the acquired kallikrein deficiency.
The acquired deficiency can be caused by interference of synthesis serious liver disease as well as by an increased consumption e. Diluted sample. For the acid-stopped method: read the absorbance at nm within 4 hours. If the plasma is icteric, hemolytic or lipemic, plasma blanks should be determined. Plasma blank is prepared by adding the reagents in reverse order starting with the acetic acid, without incubation.
Subtract the absorbance of the blank from the absorbance of the corresponding sample. Discussion The pathophysiological significance of plasma PK independent of its role in blood coagulation is just beginning to be realized.
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In vitro activation of the contact Hageman Factor system of plasma by heparin and chondroitin sulfate E. Kinetics of activation and autoactivation of human factor XII. Autoactivation of human plasma prekallikrein. Local bradykinin formation is controlled by glycosaminoglycans. J immunology. The laboratory test results are NOT to be interpreted as results of a "stand-alone" test.
Your healthcare providers will explain the meaning of your tests results, based on the overall clinical scenario. Certain medications that you may be currently taking may influence the outcome of the test. Hence, it is important to inform your healthcare provider of the complete list of medications including any herbal supplements you are currently taking.
This will help the healthcare provider interpret your test results more accurately and avoid unnecessary chances of a misdiagnosis. Kee, J. Laboratory and diagnostic tests with nursing implications 8th ed. Lab Tests Online , January Martini, F. San Francisco: Benjamin Cummings. Williamson, M. Wallach's interpretation of diagnostic tests 9th ed. Golas, A.
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